Integrated Genome-Scale Prediction of Detrimental Mutations in Transcription Networks
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چکیده
منابع مشابه
Integrated Genome-Scale Prediction of Detrimental Mutations in Transcription Networks
A central challenge in genetics is to understand when and why mutations alter the phenotype of an organism. The consequences of gene inhibition have been systematically studied and can be predicted reasonably well across a genome. However, many sequence variants important for disease and evolution may alter gene regulation rather than gene function. The consequences of altering a regulatory int...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2011
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002077